[HTML][HTML] Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36
J Chean, CJ Chen, G Gugiu, P Wong, S Cha… - Journal of Biological …, 2021 - ASBMB
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in the
liver and secreted as biliary glycoprotein 1 (BGP1) via bile canaliculi (BCs). CEACAM1-LF is
a 72 amino acid cytoplasmic domain mRNA splice isoform with two immunoreceptor tyrosine-
based inhibitory motifs (ITIMs). Ceacam1−/− or Ser503Ala transgenic mice have been
shown to develop insulin resistance and nonalcoholic fatty liver disease; however, the role
of the human equivalent residue, Ser508, in lipid dysregulation is unknown. Human HepG2 …
liver and secreted as biliary glycoprotein 1 (BGP1) via bile canaliculi (BCs). CEACAM1-LF is
a 72 amino acid cytoplasmic domain mRNA splice isoform with two immunoreceptor tyrosine-
based inhibitory motifs (ITIMs). Ceacam1−/− or Ser503Ala transgenic mice have been
shown to develop insulin resistance and nonalcoholic fatty liver disease; however, the role
of the human equivalent residue, Ser508, in lipid dysregulation is unknown. Human HepG2 …
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